Synfacts 2009(4): 0423-0423  
DOI: 10.1055/s-0028-1087874
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Desymmetrizing Hydroformylation/Carbonyl Ene Cyclization

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
A. Bigot, D. Breuninger, B. Breit*
Albert-Ludwigs-Universität Freiburg, Germany
Further Information

Publication History

Publication Date:
23 March 2009 (online)


The combination of multiple operations within a single flask provides chemists with efficient and practical methods for construction of complex compounds without the need for intermediary purification. This report shows the scope and limitation of a previously reported method for one-pot desymmetrizing hydroformylation and subsequent carbonyl ene cyclization. This process provides highly functionalized cyclohexanols whose synthesis would typically require several steps.