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Desymmetrizing Hydroformylation/Carbonyl Ene Cyclization
A. Bigot, D. Breuninger, B. Breit*
Albert-Ludwigs-Universität Freiburg, Germany
23 March 2009 (online)
The combination of multiple operations within a single flask provides chemists with efficient and practical methods for construction of complex compounds without the need for intermediary purification. This report shows the scope and limitation of a previously reported method for one-pot desymmetrizing hydroformylation and subsequent carbonyl ene cyclization. This process provides highly functionalized cyclohexanols whose synthesis would typically require several steps.