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Synfacts 2009(4): 0420-0420  
DOI: 10.1055/s-0028-1087876
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Three-Component Reactions to Benzoxazines

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
X. Xu, L. Liang, J. Liu, J. Yang, L. Mai, Y. Li*
East China Normal University, Shanghai, P. R. of China
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Publication History

Publication Date:
23 March 2009 (online)

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Significance

The authors described the development of an efficient one-pot synthesis of 1,4-benzoxazines through copper-catalyzed three-component coupling reactions. The resulting 1,4-benzoxazines were obtained in good to high yields. Furthermore, the O-annulation proceeded in a completely regio- and stereoselective manner. Only the six-membered rings and Z-isomers were obtained.