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Synthesis of 5-Alkoxycyclohex-2-enones by Ring-Closing Metathesis
M. Turks, P. Vogel*
Swiss Federal Institute of Technology, Lausanne, Switzerland
23 March 2009 (online)
The authors reported the synthesis of optically active 5-alkoxy-6-methylcyclohex-2-en-1-one derivatives. The synthesis of these compounds is a challenge because they are prone to undergo β-eliminations generating the corresponding phenols, under basic or acidic conditions. Because of the neutral conditions for ring-closing metathesis, 5-alkoxycyclohex-2-enone could be obtained without β-elimination.