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Asymmetric Gold-Catalyzed Enyne Cyclization
C.-M. Chao, M. R. Vitale, P. Y. Toullec, J.-P. Genêt, V. Michelet*
Ecole Nationale Supérieure de Chimie de Paris, France
23 March 2009 (online)
The authors describe a tandem cycloisomerization of 1,6-enynes using a gold catalyst and aromatic nucleophiles. Although this class of reactions is well characterized (see Review below), enantioselective variants are much less common. A moderate scope is demonstrated achieving high yields and enantioselectivities.
Review: N. Bongers, N. Krause Angew. Chem. Int. Ed. 2008, 47, 2178-2181.