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Palladium-Catalyzed Asymmetric Reductive Amination of Ketones
L. Rubio-Pérez*, F. J. Pérez-Flores, P. Sharma, L. Velasco, A. Cabrera
Universidad Nacional Autónoma de México, México
23 March 2009 (online)
In recent years, asymmetric reductive amination chemistry has attracted considerable interest. In the present paper, the palladium-catalyzed asymmetric reductive amination of ketones is described. Using preformed chiral palladium complexes the target amines can be obtained in high yield and with good enantioselectivity. It is reported that under these reaction conditions reduction of the ketones to the corresponding alcohols is not observed.
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