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Synfacts 2009(4): 0351-0351  
DOI: 10.1055/s-0028-1088080
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Aburatubolactam A

Contributor(s): Philip Kocienski, Arndt W. Schmidt
J. A. Henderson, A. J. Phillips*
University of Colorado, Boulder, USA
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Publication History

Publication Date:
23 March 2009 (online)

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Significance

Aburatubolactam A was isolated from the culture broth of a Streptomyces sp. and displays a variety of biological activities such as cytotoxicity, antimicrobial activity and inhibition of superoxide generation. This synthesis features a ring-opening/ring-closing metathesis to construct the bicyclo[3.3.0]octane subunit and a late-stage macrolactamization.