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Total Synthesis of (-)Clavirolide C
M. K. Brown, A. H. Hoveyda*
Boston College, Chestnut Hill, USA
23 March 2009 (online)
The first enantioselective total synthesis of (-)-clavirolide C is noteworthy for the use of different types of copper-catalyzed asymmetric conjugate additions to make both the fragments E and F as well as the final molecule. Also the phosphine-free ruthenium-based ring-closing metathesis to form the 11-membered ring is a rare example of its kind.