Download PDF
Synfacts 2009(4): 0357-0357  
DOI: 10.1055/s-0028-1088091
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Podophyllotoxin

Contributor(s): Philip Kocienski, Zofia Komsta
D. Stadler, T. Bach*
Technische Universität München, Garching, Germany
Further Information

Publication History

Publication Date:
23 March 2009 (online)

    Permissions and Reprints

Significance

Podophyllotoxin is obtained from the rhizome of American mayapple. It possesses some cytotoxic and antiviral properties. The short synthesis depicted features an iron(III)-catalyzed diastereoselective Friedel-Crafts alkylation (C → E).