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Formal Synthesis of Tamiflu®
M. Matveenko, A. C. Willis, M. G. Banwell*
The Australian National University, Canberra, Australia
23 March 2009 (online)
Tamiflu® is used as a treatment for influenza as well as to prevent infections. The active drug is the free acid which inhibits the enzymes necessary for viral replication, neuraminidases A and B. The synthesis of Banwell and co-workers starts with the commercial diol A, which is derived from microbial dihydroxylation of bromobenzene.