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Synfacts 2009(5): 0576-0576  
DOI: 10.1055/s-0029-1216559
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cyclization Reaction with Silaphenylmercuric Triflate

Contributor(s): Yasuhiro Uozumi, Yoshinori Hirai
H. Yamamoto*, I. Sasaki, Y. Hirai, K. Namba, H. Imagawa, M. Nishizawa*
Tokushima Bunri University, Japan
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

Silaphenylmercuric triflate 2 was obtained by the reaction of compound 1 with Hg(OAc)2 in AcOH under microwave conditions, followed by anion exchange with TfOH (eq. 1). The cyclization of alkyne derivatives proceeded with catalyst 2 (5-20 mol% of Hg) to give the corresponding cyclic compounds in up to 99% yield (eq. 2, 9 examples).