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Synfacts 2009(5): 0521-0521  
DOI: 10.1055/s-0029-1216620
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Strontium Catalyst for Asymmetric Michael Addition

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
S. Kobayashi*, M. Yamaguchi, M. Agostinho, U. Schneider
The University of Tokyo, Japan
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

The enantioselective Michael addition is a highly important C-C bond formation ­reaction. Most reported asymmetric Michael additions employ expensive catalysts and/or metals along with several equivalents of nucleophiles that are required. Reported is a highly enantioselective, robust, alkaline earth metal catalyst Michael addition of malonates to chalcone derivatives.