Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(6): 0581-0581
DOI: 10.1055/s-0029-1216673
DOI: 10.1055/s-0029-1216673
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (+)-Cortistatin A
H. M. Lee, C. Nieto-Oberhuber, M. D. Shair*
Harvard University, Cambridge, USA
Further Information
Publication History
Publication Date:
25 May 2009 (online)
Significance
Cortistatin A was isolated together with structurally related molecules from the sponge Corticium simplex. It shows potent anti-angiogenetic activity with a high selectivity towards several human and murine cancer cell lines. The focal step of the synthesis is a highly stereoselective aza-Prins cyclization to complete the steroid-like carbon framework (G → H).