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Synthesis of (+)-Cortistatin A
H. M. Lee, C. Nieto-Oberhuber, M. D. Shair*
Harvard University, Cambridge, USA
25 May 2009 (online)
Cortistatin A was isolated together with structurally related molecules from the sponge Corticium simplex. It shows potent anti-angiogenetic activity with a high selectivity towards several human and murine cancer cell lines. The focal step of the synthesis is a highly stereoselective aza-Prins cyclization to complete the steroid-like carbon framework (G → H).