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N to C Aryl Migration in Lithiated Carbamates
J. Clayden*, W. Farnaby, D. M. Grainger, U. Hennecke, M. Mancinelli, D. J. Tetlow, I. H. Hillier*, M. A. Vincent
University of Manchester, UK
25 May 2009 (online)
Lithiated carbamates undergo versatile reactions ranging from simple quenching with electrophiles to 1,2-acyl transfer reactions providing α-hydroxamides. In this article, a remarkable N to C 1,4-aryl migration in lithiated carbamates is described. This method can be efficiently used for the synthesis of α-arylated benzylic alcohols.