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Palladium-Catalyzed Asymmetric Suzuki-Miyaura Coupling in Water
Y. Uozumi*, Y. Matsuura, T. Arakawa, Y. M. A. Yamada
Institute for Molecular Science, Okazaki and RIKEN, Wako, Japan
25 May 2009 (online)
The authors reported an asymmetric Suzuki-Miyaura coupling in water with a recyclable palladium complex of a chiral imidazoindole phosphine ligand supported on an amphiphilic PS-PEG resin. The cross-coupled products were obtained in high enantioselectivities and high yields. The catalyst was readily recovered and reused four times without significant loss of catalytic activity and stereoselectivity.