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Synfacts 2009(6): 0643-0643
DOI: 10.1055/s-0029-1216781
DOI: 10.1055/s-0029-1216781
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective, Copper-Catalyzed Three-Component Reaction
Z. Shao*, X. Pu, X. Li, B. Fan, A. S. C. Chan*
The Hong Kong Polytechnic University and Yunnan University, Kunming, P. R. of China
Further Information
Publication History
Publication Date:
25 May 2009 (online)
Significance
As an extension on previous research concerning the asymmetric synthesis of aliphatic alkynyl α-amino acid derivatives (Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 11196), the authors now describe the copper-catalyzed three-component reaction between ethyl glyoxylate, 4-anisidine and alkynes. The β,γ-alkynyl α-amino acid derivatives are obtained in good yield and enantioselectivity.