Synfacts 2009(6): 0653-0653  
DOI: 10.1055/s-0029-1217195
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Cross-Trimerization between TIPSA and Internal Alkynes with Ni Complex

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
K. Ogata*, H. Murayama, J. Sugasawa, N. Suzuki, S.-i. Fukuzawa*
Chuo University, Tokyo and RIKEN, Wako, Japan
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Publication History

Publication Date:
25 May 2009 (online)


The authors reported the effec-tive 1:2 cross-trimerization of alkynes using a Ni(cod)2/n-Pr3P catalyst. The cross-trimerization products between triisopropylsilylacetylene (TIPSA) and symmetrical and asymmetrical internal alkynes were obtained with high regio- and stereoselectivity. They propose the possible pathway for the trimerization which is similar to that for the nickel-catalyzed dimerization of alkynes.