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Synfacts 2009(7): 0810-0810  
DOI: 10.1055/s-0029-1217228
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Strecker Reaction with Superparamagnetic Iron Oxide

Contributor(s): Yasuhiro Uozumi, Yoshikazu Yamamoto
M. M. Mojtahedi*, M. S. Abaee*, T. Alishiri
Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

Superparamagnetic iron oxide (Fe3O4) catalyzed the solvent-free Strecker reaction of TMSCN, aldehydes, and amines to afford the corresponding α-aminonitriles in up to 95% yield (18 examples). The reaction of (S)-1-phenylethylamine, benzaldehyde, and TMSCN proceeded to give 1j in 88% yield with 60% de.