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Synthesis of Bottromycin A2
H. Shimamura, H. Gouda, K. Nagai, T. Hirose, M. Ichioka, Y. Furuya, Y. Kobayashi, S. Hirono, T. Sunazuka*, S. Õmura*
Kitasato University, Tokyo, Japan
22 June 2009 (online)
Bottromycin is an antibiotic against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). It has a novel mode of action: it inhibits bacterial protein synthesis by blocking the binding of aminoacyl-tRNA to the A site on the 50S ribosome. No cross resistance to existing drugs has been observed.