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Synthesis of Sphingosine
J. Llaveria, Y. Díaz, M. I. Matheu*, S. Castillón*
Universitat Rovira u Virgili, Tarragona, Spain
22 June 2009 (online)
Sphingosine is a core component of glycosphingolipids, a class of cell membrane lipids which serve as an anchor for polysaccharides on the surface of all eukaryotic cells. A very efficient enantioselective synthesis starting from a simple racemic material is presented using Trost’s dynamic kinetic asymmetric allylic substitution reaction as the key step (A → C).