Synfacts 2009(7): 0710-0710  
DOI: 10.1055/s-0029-1217250
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Trichodermamide B

Contributor(s): Philip Kocienski, Stewart Eccles
X. Wan, M. M. Joullié*
University of Pennsylvania, Philadelphia, USA
Further Information

Publication History

Publication Date:
22 June 2009 (online)


Both trichodermamides A and B were isolated from the marine-derived fungus ­Trichoderma virens. Trichodermamide B possesses cytotoxic activity with an IC50 of 0.32 µg/mL against HCT-116 colon carcinoma. The molecule contains a rare oxazine ring system.