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Synfacts 2009(7): 0777-0777
DOI: 10.1055/s-0029-1217254
DOI: 10.1055/s-0029-1217254
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Carboxylation of Organozinc Reagents Using CO2 in DMF
K. Kobayashi, Y. Kondo*
Tohoku University, Sendai, Japan
Further Information
Publication History
Publication Date:
22 June 2009 (online)
Significance
This is the first report on the transition-metal-free carboxylation of organozinc compounds. Functionalized alkyl-, alkenyl-, benzylic, and arylzinc compounds prepared by a variety of methods can be involved in this reaction affording good yields of the corresponding acids. This is a simple and useful method for the preparation of functionalized carboxylic acids.