Synfacts 2009(7): 0777-0777  
DOI: 10.1055/s-0029-1217254
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Carboxylation of Organozinc Reagents Using CO2 in DMF

Contributor(s): Paul Knochel, Andrei Gavryushin
K. Kobayashi, Y. Kondo*
Tohoku University, Sendai, Japan
Further Information

Publication History

Publication Date:
22 June 2009 (online)

Significance

This is the first report on the transition-metal-free carboxylation of organozinc compounds. Functionalized alkyl-, alkenyl-, benzylic, and arylzinc compounds prepared by a variety of methods can be involved in this reaction affording good yields of the corresponding acids. This is a simple and useful method for the preparation of functionalized carboxylic acids.