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Ir(I)-Catalyzed sp³ C-H Bond Alkenylation of Amides with Alkynes
K. Tsuchikawa, M. Kasagawa, K. Endo, T. Shibata*
Waseda University, Tokyo, Japan
22 June 2009 (online)
The direct functionalization of unactivated sp³ C-H bonds has currently attracted a lot of attention. This iridium(I)-catalyzed C-H bond alkenylation allows for a straightforward construction of highly substituted allylic amides. This interesting carbonyl-directed sp³ C-H bond cleavage by iridium(I) leads to new developments in the growing field of C-H activation chemistry.