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One-Pot Synthesis of N-Arylpyrazoles from Aryl Halides
B. S. Gerstenberger*, M. R. Rauckhorst, J. T. Starr
Pfizer Global Research and Development, Groton, USA
22 June 2009 (online)
A facile one-pot synthesis of functionalized pyrazoles from aryllithium or arylmagnesium compounds, di-tert-butylazodicarboxylate (DBAD) as hydrazine equivalent and 1,3-dicarbonyl compounds or equivalents thereof is reported affording the desired pyrazoles in good yields.