Synfacts 2009(7): 0780-0780  
DOI: 10.1055/s-0029-1217260
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

One-Pot Synthesis of N-Arylpyrazoles from Aryl Halides

Contributor(s): Paul Knochel, Andreas J. Wagner
B. S. Gerstenberger*, M. R. Rauckhorst, J. T. Starr
Pfizer Global Research and Development, Groton, USA
Further Information

Publication History

Publication Date:
22 June 2009 (online)


A facile one-pot synthesis of functionalized pyrazoles from aryllithium or arylmagnesium compounds, di-tert-butylazodicarboxylate (DBAD) as hydrazine equivalent and 1,3-dicarbonyl compounds or equivalents thereof is reported affording the desired pyrazoles in good yields.