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Synthesis of Chiral Biaryl Compounds Through Cycloisomerization
H. Imase, T. Suda, Y. Shibata, K. Noguchi, M. Hirano, K. Tanaka*
Tokyo University of Agriculture and Technology, Japan
22 June 2009 (online)
Biaryl motifs possessing axial chirality are common in biologically active compounds and are often utilized in chiral ligands. The use of cycloadditions and cycloisomerizations to access such structures has been explored more recently. The authors report a palladium-catalyzed version of this reaction constructing 4-aryl-2-pyridones (2) in good yields and selectivities.