Synfacts 2009(7): 0768-0768  
DOI: 10.1055/s-0029-1217270
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Chiral Biaryl Compounds Through Cycloisomerization

Contributor(s): Mark Lautens, Jane Panteleev
H. Imase, T. Suda, Y. Shibata, K. Noguchi, M. Hirano, K. Tanaka*
Tokyo University of Agriculture and Technology, Japan
Further Information

Publication History

Publication Date:
22 June 2009 (online)


Biaryl motifs possessing axial chirality are common in biologically active compounds and are often utilized in chiral ligands. The use of cycloadditions and cycloisomerizations to access such structures has been explored more recently. The authors report a palladium-catalyzed version of this reaction constructing 4-aryl-2-pyridones (2) in good yields and selectivities.