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Iridium-Salen-Catalyzed Synthesis of Spirocyclopropyl Lactones
M. Ichinose, H. Suematsu, T. Katsuki*
Kyushu University, Fukuoka, Japan
22 June 2009 (online)
There are several known methods for the construction of chiral 1,4-cylcoheptadienes. Of the reported methods only low to moderate yields and moderate enantioselectivities were observed. In this report Katsuki has expanded on his previous findings of iridium-salen-catalyzed cyclopropanation to furnish α-spirocyclopropyl lactones, which were later derivatized via a Cope rearrangement to give chiral 1,4-cycloheptadienes.