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Copper-Catalyzed Directed Carbozincation of Cyclopropenes
V. Tarwade, X. Liu, N. Yan, J. M. Fox*
University of Delaware, Newark, USA
22 June 2009 (online)
The authors have developed a Cu-catalyzed diastereoselective addition of organozinc reagents to cyclopropene derivatives. Either ester or oxazolidinone is an excellent directing group in the addition of a variety of organozinc reagents with excellent facial selectivity. The scope of the method is broadened by the ability to utilize organozinc reagents generated in situ from Grignard reagents.