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Zinc-Catalyzed Direct Asymmetric Vinylogous Michael Addition
B. M. Trost*, J. Hitce
Stanford University, USA
22 June 2009 (online)
This paper described the dinuclear zinc-catalyzed direct asymmetric Michael addition to nitroalkenes. This methodology provided synthetically useful γ-substituted butenolides in high yields and excellent enantioselectivities. Furthermore, the authors have extended the scope of the dinuclear zinc catalyst to vinylogous nucleophilicity.