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Elemental Copper Catalyzed Stereoselective Aminobromination
Z.-G. Chen, J.-F. Wei*, R.-T. Li, X.-Y. Shi, P.-F. Zhao
Shaanxi Normal University and Peking University, Beijing, P. R. of China
22 June 2009 (online)
Stereoselective aminohalogenation is a challenging problem for organic synthesis. In this report, a convenient procedure for aminobromination of α,β-unsaturated ketones catalyzed by copper powder is described. The method can provide the aminobromination products in almost quantitative yields and complete anti-selectivity with only 1 mol% catalyst loading under aerial conditions. Copper metal was also proven to be more efficient than CuI in this transformation.