Synfacts 2009(7): 0773-0773  
DOI: 10.1055/s-0029-1217295
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ir-Catalyzed N-Heterocyclization for Enantio-selective Synthesis of Noranabasamine

Contributor(s): Hisashi Yamamoto, Pingfan Li
L. Miao, S. C. DiMaggio, H. Shu, M. L. Trudell*
University of New Orleans, USA
Further Information

Publication History

Publication Date:
22 June 2009 (online)


Yamaguchi’s iridium-catalyzed N-heterocyclization reaction of diols with primary amines is utilized for the short total synthesis of both enantiomers of noranabasamine. The absolute configuration of this natural product is also established.