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Copper-Catalyzed Synthesis of 2-Substituted Oxazolopyridines
D. Xu, X. Xu, Z. Liu, L.-P. Sun*, Q. You
China Pharmaceutical University, Nanjing and Sun Yat-sen University, Guangzhou, P. R. of China
22 June 2009 (online)
Reported is the synthesis of oxazolo[5,4-b]pyridines and oxazolo[4,5-b]pyridines by copper-catalyzed intramolecular C-O coupling reactions. The substrate scope was reasonably well examined and appears to be general for R¹, R² = Ar substituents. However, low yields of products were obtained when R¹, R² = Et or 2-pyridyl substitution was attempted.