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Synfacts 2009(8): 0826-0826  
DOI: 10.1055/s-0029-1217577
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Phorbasin C

Contributor(s): Philip Kocienski, Indu Dager
T. K. Macklin, G. C. Micalizio*
Yale University, New Haven, USA
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Publication History

Publication Date:
23 July 2009 (online)

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Significance

Members of the phorbasin class of diterpenes inhibit Gram positive bacteria like Staphylococcus aureus and Micrococcus luteuss. This first total synthesis of (+)-phorbasin C uses an allylic alcohol-alkyne reductive cross-coupling reaction a a key step and also determines the correct stereochemistry of the molecule.