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Synfacts 2009(9): 1003-1003  
DOI: 10.1055/s-0029-1217637
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Hydrogenation of
α,β-Unsaturated Amides

Contributor(s): Hisashi Yamamoto, Pingfan Li
W.-J. Lu, X.-L. Hou*
Shanghai Institute of Organic Chemistry, P. R. of China
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Publikationsdatum:
21. August 2009 (online)

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Significance

An iridium/chiral P,N-ligand complex catalyzed hydrogenation of α,β-unsaturated amides is developed. High conversion and enan­tioselectivities are obtained even with aliphatic amide substrates. The presence of hydrogen on the amide nitrogen is found to be crucial for good results.