Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides

Significance

Direct cross-coupling of secondary acyclic organometallic species is a rather challenging task. This reaction is often plagued by β-hydride elimination or metal migration. The fine tuning of the ligand for the Negishi coupling allowed the development of a high-yielding, simple procedure for this coupling reaction, suitable for a broad substrate range with excellent functional group tolerance.