Synthesis of Norhalichondrin B

K. L. Jackson; J. A. Henderson; H. Motoyoshi; A. J. Phillips

doi:10.1055/s-0029-1217866

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Synfacts 2009(10): 1059-1059
DOI: 10.1055/s-0029-1217866

Synthesis of Natural Products and Potential Drugs

Synthesis of Norhalichondrin B

Contributor(s): Philip Kocienski, Stewart Eccles
K. L. Jackson, J. A. Henderson, H. Motoyoshi, A. J. Phillips*
University of Colorado, Boulder, USA

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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Norhalichondrin B is a marine polyether with potent cytotoxicity. Key to this synthetic approach are the Nozaki-Hiyama-Kishi reactions and the tandem Achmatowicz oxidation-ionic hydrogenation which form the pyranopyran systems.