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Synfacts 2009(11): 1186-1186
DOI: 10.1055/s-0029-1218032
DOI: 10.1055/s-0029-1218032
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (-)-Napyradiomycin A1
S. A. Snyder*, Z.-Y. Tang, R. Gupta
Columbia University, New York, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Oktober 2009 (online)
Significance
Napyradiomycins are a class of compounds isolated from several strains of terrestrial Streptomyces bacteria. They are nonsteroidal estrogen antagonists. The synthesis of napyradiomycin A1 uses a novel asymmetric chlorination to introduce one of the chlorine groups and control the stereochemistry of the geranyl side chain.