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Cross-Coupling of Organozinc Reagents with Thiomethylated Heterocycles
A. Metzger, L. Melzig, C. Despotopoulou, P. Knochel*
Ludwig-Maximilians-Universität, München, Germany
20 November 2009 (online)
A broad number of thiomethyl-substituted heterocycles like pyridines, pyrimidines, triazines, pyrazoles, quinazolines, etc. can be coupled at room temperature with readily available functionalized aryl-, heteroaryl-, benzyl- and alkyl-zinc compounds in the presence of a Pd/S-Phos catalytic system. This is an excellent method for the preparation of polysubstituted heterocycles.