Synfacts 2009(12): 1407-1407  
DOI: 10.1055/s-0029-1218215
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Nucleophilic Addition γ to the Carbonyl Group

Contributor(s): Benjamin List, Anna Lee
S. W. Smith, G. C. Fu*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
20 November 2009 (online)


The authors report a remarkable phosphine-catalyzed γ-addition to a carbonyl group using a carbon nucleophile. The reaction provides products in moderate to good yields (57-94%) and high enantioselectivities (er up to 98.5:1.5).