Subscribe to RSS
Rhodium-Catalyzed Asymmetric Hydrogenation
D. A. Rankic, J. M. Hopkins, M. Parvez, B. A. Keay*
University of Calgary, Canada
20 November 2009 (online)
In this paper the authors report the synthesis and resolution of 3,3′-disubstituted xylBINAP derivatives and their application as ligands for rhodium-catalyzed asymmetric hydrogenation of dehydroamino acids and enamides. Under optimized conditions ligand 5, bearing chiral moieties at the 3,3′-positions, demonstrated excellent results for hydrogenation of methyl N-acetamido cinnamic acid (>99% ee).