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Synthesis of (-)-Amphidinolide X
J. H. Jung, E. Lee*
Seoul National University, Korea
20 November 2009 (online)
Amphidinolide X is a metabolite of laboratory-cultured dinoflagellates of the genus Amphidinium. The salient feature of this synthesis is the construction of the tetrahydrofuran ring bearing a quaternary center via a SmI2-mediated 5-exo-reductive cyclization (F → G → H).