Synfacts 2009(12): 1311-1311  
DOI: 10.1055/s-0029-1218323
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Amphidinolide X

Contributor(s): Philip Kocienski
J. H. Jung, E. Lee*
Seoul National University, Korea
Further Information

Publication History

Publication Date:
20 November 2009 (online)


Amphidinolide X is a metabolite of laboratory-cultured dinoflagellates of the genus Amphidinium. The salient feature of this synthesis is the construction of the tetrahydrofuran ring bearing a quaternary center via a SmI2-mediated 5-exo-reductive cyclization (FGH).