Subscribe to RSS
Formal Synthesis of (-)-Cochleamycin A
S. Mukherjee, D. Lee*
University of Illinois at Chicago, USA
20 November 2009 (online)
Cochleamycin A is a Streptomyces metabolite with significant antibiotic activity against Gram-positive bacteria and cytotoxicity towards P388 leukemia cells. The key step in the synthesis of K, an intermediate in Roush’s synthesis, is an intramolecular ring-closing metathesis of the silaketal I to give the (E,Z)-diene J in ca. 61% yield.