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Synfacts 2010(9): 0974-0974  
DOI: 10.1055/s-0030-1257933
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-6-epi-Castanospermine

Contributor(s): Steven V. Ley, Catherine F. Carter
J. Louvel, C. Botuha, F. Chemla*, E. Demont, F. Ferreira, A. Pérez-Luna
Université Paris 6, France and GlaxoSmithKline, Stevenage, UK
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Publikationsdatum:
23. August 2010 (online)

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Significance

(+)-6-epi-Castanospermine is an alkaloid isolated from the pod seeds of Castanospermum australe and has been shown to inhibit α-glycosidases. The total synthesis was achieved in 8.5% overall yield from A.