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Synfacts 2010(9): 0972-0972  
DOI: 10.1055/s-0030-1257934
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Englerin A

Contributor(s): Steven V. Ley, Kimberley A. Roper
Q. Zhou, X. Chen, D. Ma*
Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

(-)-Englerin A, a sesquiterpene ­diester recently isolated from Phylanthus engleri, inhibits renal cancer cell growth with nanomolar potency. This synthesis was published back-to-back with Echavarren and co-workers (see next Synfact) who used a similar methodology (Angew. Chem. Int. Ed. 2006, 45, 5452). A previous synthetic route involved a ring contraction and Grubbs metathesis (M. Christmann and co-workers Angew. Chem. Int. Ed. 2009, 48, 9105).