Synfacts 2010(9): 1089-1089  
DOI: 10.1055/s-0030-1257984
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Aza-Michael Addition in Alkaline Al2O3

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
X. Ai, X. Wang*, J.-M. Liu, Z.-M. Ge, T.-M. Cheng, R.-T. Li*
Peking University, Beijing, P. R. of China
Further Information

Publication History

Publication Date:
23 August 2010 (online)

Significance

The alkaline Al2O3 mediated aza-Michael addition of aromatic or aliphatic amines (primary or secondary) to electron-deficient al­kenes was described. The aza-Michael addition of aniline to acrylonitrile was carried out with alkaline Al2O3 to afford 3-(phenylamino)propionitrile 3a in 98% yield.