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Synfacts 2011(1): 0046-0046  
DOI: 10.1055/s-0030-1258988
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Stereoselective [3+2] Cycloaddition of Imino Esters with Nitroalkenes

Contributor(s): Hisashi Yamamoto, Patrick Brady
T. Arai*, N. Yokoyama, A. Mishiro, H. Sato
Chiba University and Rigaku Corporation, Tokyo, Japan
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Publikationsdatum:
21. Dezember 2010 (online)

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Significance

A library of solid-phase imidazoline-aminophenol/metal catalysts was prepared and a high-throughput screening method employing analysis by circular dichroism spectroscopy was used to find the most selective catalyst. This is the first method to generate exo′ products in high diastereoselectivity and with excellent ee ­values.