Synfacts 2011(1): 0080-0080  
DOI: 10.1055/s-0030-1259113
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Selective C4 Alkylation of Pyridines Using Nickel/Lewis Acid Catalysis

Contributor(s): Paul Knochel, Tobias Thaler
Y. Nakao*, Y. Yamada, N. Kashihara, T. Hiyama*
Kyoto University, Japan
Further Information

Publication History

Publication Date:
21 December 2010 (online)


A direct C4-selective addition of pyridine across alkenes via nickel/Lewis acid ­cocatalysis has been described. The method ­proceeds highly regioselectively furnishing the ­linear 4-alkylpyridines in modest to good yields. Branched 4-alkylpyridines are obtained when ­styrenes are used.