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Selective C4 Alkylation of Pyridines Using Nickel/Lewis Acid Catalysis
Y. Nakao*, Y. Yamada, N. Kashihara, T. Hiyama*
Kyoto University, Japan
21 December 2010 (online)
A direct C4-selective addition of pyridine across alkenes via nickel/Lewis acid cocatalysis has been described. The method proceeds highly regioselectively furnishing the linear 4-alkylpyridines in modest to good yields. Branched 4-alkylpyridines are obtained when styrenes are used.