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A New Palladium Precatalyst for the Suzuki Coupling of Unstable Boronic Acids
T. Kinzel, Y. Zhang, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
21 December 2010 (online)
Polyfluorophenylboronic and five-membered 2-heteroaromatic boronic acids are known to quickly deboronate under basic conditions and are therefore challenging substrates for the Suzuki-Miyaura coupling. Herein, a novel palladium catalyst is reported, which enables the coupling of such unstable boronic acids to a wide range of (hetero)aryl chlorides, bromides, and triflates in short reaction times and excellent yields.