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Synthesis of (-)-Spongidepsin
Y. Zhu, A. Loudet, K. Burgess*
Texas A&M University, College Station, USA
21 December 2010 (online)
(-)-Spongidepsin is a polyketide natural product isolated from the Vanuatu marine sponge Spongia sp. It exhibits cytotoxic and anti-proliferative activity against certain cancer cell lines. (-)-Spongidepsin contains a 13-membered cyclodepsipeptide ring, a terminal acetylene, and five stereocenters.