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Synfacts 2011(1): 0108-0108  
DOI: 10.1055/s-0030-1259134
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Reduction of Nitrobenzenes and Oxidation of Alcohols with M-DNA

Contributor(s): Yasuhiro Uozumi, Takao Osako
Y. Wang, G. Ouyang, J. Zhang, Z. Wang*
University of Science and Technology of China, Hefei, P. R. of China
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

Metal-DNA nanohybrids (M-DNA: M = Pd, Au, Ag, and Pt) were prepared by treatment of fish sperm DNA with the metal salts followed by reduction with NaBH4 (eq. 1). Pd-DNA catalyzed the hydrogenation of nitrobenzenes in Tris buffer to give the corresponding anilines in 80-99% yield (10 examples, eq. 2). Au-DNA was effective for the oxidation of secondary alcohols with oxygen to afford the corresponding ketones in 60 to >99% yield (9 examples, eq. 3).