Synfacts 2011(1): 0064-0064  
DOI: 10.1055/s-0030-1259160
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Asymmetric Hydrogenation of Exocyclic Ketones, Lactones, and Lactams

Contributor(s): Hisashi Yamamoto, Zhi Li
F. Tian, D. Yao, Y. Liu, F. Xie, W. Zhang*
Shanghai Jiao Tong University, P. R. of China
Further Information

Publication History

Publication Date:
21 December 2010 (online)

Significance

The authors discovered a very efficient iridium-catalyzed process for asymmetric hydrogenation of exocyclic α,β-unsaturated carbonyl compounds using axis-unfixed phosphine oxazoline ligands. Five-membered exocyclic α,β-unsaturated ketones, lactones, and lactams were hydrogenated to generate corresponding α-chiral carbonyl compounds in high conversion and enantioselectivities.